Fignani D. et al. were able to not only demonstrate ACE2 staining in islet β-cells but were also able to demonstrate that inflammatory cytokines (Il-1β, IFNγ and TNFα) were capable of upregulating ACE2 in islet β-cells and thus support the importance of cytokine storm (hyperinflammation) and/or cytokine release syndrome in COVID-19 [73]. This evidence concerns the gene ACE2 and COVID-19.