Among them, Korkmas et al. showed that chronic administration of 7,8-dihydroxyflavone significantly improved motor deficits and enhanced lower neuronal survival in the transgenic ALS mouse model [215], whereas Ip et al. found that quercetin and its derivative could be therapeutic inhibitors of the aggregation and misfolding of SOD1 that is noticed in ALS [216]. Here, SOD1 is linked to amyotrophic lateral sclerosis.