CYP2D6 and liver cancer: Among the CYP genes, four (2C19, 2C8, 2C9, 3A5) showed significant associations with increased OS rates in liver cancer (LIHC); three showed correlation with reduced (2D6, E1) or increased (3A4) OS rates in kidney cancer (KIRC); CYP2D6 was also associated with increased OS rates in breast cancer (BRCA) (Figure 1).