CSCs maintenance also seems to depend upon the size of the pool of monounsaturated fatty acids (MUFAs) generated by the activity of the stearoyl-CoA desaturase 1 (SCD1) [37,76,77,78] because SCD1 inhibition was shown to selectively eliminate CSCs in lung cancer, both alone and in synergy with chemotherapy [79,80]. Here, SCD is linked to lung cancer.