Our study shows that the two SLRPs or secreted ECM, osteomodulin (OMD) and proline/arginine-rich end leucine repeat protein (PRELP) are expressed in bladder and critical regulators of bladder cancer initiation and progression via altering cell–cell adhesion, probably through the regulation of epithelial–mesenchymal transition (EMT). The gene discussed is PRELP; the disease is urinary bladder cancer.