To confirm that all of the expressed cytokines could potentially bind and activate their receptors in tumor cells, the mRNA expression of interferon-α/β receptors (Ifnar1 and Ifnar2), tumor necrosis factor receptor (Tnfr), and interleukin 1 receptor type 1 and 2 (Il1r1 and Il1r2) was evaluated. The gene discussed is IL1R2; the disease is neoplasm.