We investigated the NPRL3 rs2541618 C>T, NPRL3 rs75187722 G>A, MPG rs2562162 C>T, and MPG rs710079 C>T polymorphisms in patients with ischemic stroke and controls, as well as by stoke subtype (LAD, SVD, and CE). This evidence concerns the gene NPRL3 and ischemic stroke.