The following showed significant associations with stroke prevalence (P < 0.05): the T-A-C allele combination of the NPRL3 rs2541618 C>T/rs75187722 G>A/MPG rs2562162 C>T polymorphisms, the C-A-C allele combination of the NPRL3 rs2541618 C>T/rs75187722 G>A/MPG rs710079 C>T polymorphisms, and the T-A-C allele combination of the NPRL3 rs2541618 C>T/rs75187722 G>A/MPG rs710079 C>T polymorphisms. This evidence concerns the gene NPRL3 and stroke disorder.