Consequently, we identified associations between the NPRL3 rs2541618 C>T, NPRL3 rs75187722 G>A, and MPG rs2562162 C>T polymorphisms with the prevalence of ischemic stroke in a Korean population as well as a significant association between NPRL3 and MPG gene polymorphisms and post-stroke mortality. Here, NPRL3 is linked to ischemic stroke.