Finally, we found that the dominant models of NPRL3 rs2541618, NPRL3 rs75187722, and MPG rs2562162 all showed synergistic effects with clinical risk factors of the SVD subtype and ischemic stroke, including platelet level, fibrinogen, hypertension, and diabetes mellitus. This evidence concerns the gene NPRL3 and snowflake vitreoretinal degeneration.