AKT1 and cancer: Further potential cancer targets involved in posttranslational regulation of the DDR include histone methyltransferases, lysine specific demethylases, HATs and HDACs [243,244,245,246,247], as well as ubiquitination and deubiquitylation enzymes and ubiquitin-specific proteases such as the Akt phosphorylation target USP14 [218,220,248,249,250].