AKT1 and cancer: In the present review, we specifically highlight the modulation of cancer metabolism as an emerging novel facet of Akt-mediated therapy resistance; in fact, accumulating evidence indicates that Akt is either directly or indirectly involved in the regulation of major metabolic processes such as glycolysis, glutaminolysis, PPP, mitochondrial metabolism, lipid metabolism, nucleotide synthesis and antioxidant defense.