Interestingly, Farrè et al. have documented in experimental models that metabolic syndrome may influence the hyperactivation of C-terminal binding protein 1 (CTBP1), a corepressor of tumor suppressor genes, determining a crucial role in breast cancer progression through metastatic cascade activation (the regulation of multiple EMT-related genes and microRNAs) [37]. The gene discussed is CTBP1; the disease is metabolic syndrome.