Focusing on cancer-related risk factors associated with poor prognoses, such as obesity-related diseases and on their molecular pathways [8,45,46] (i.e., increasing adiponectin levels using adiponectin analogs, targeting specific PPAR-signaling), can potentially become an innovative personalized treatment for breast cancer patients and metastatic disease in improving the metabolic state and, therefore, response to systemic therapies, locoregional surgery, and overall survival. The gene discussed is PPARA; the disease is breast cancer.