Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by one or more of the following manifestations: (i) renal osteodystrophy (ROD), (ii) vascular and soft tissue calcification, and (iii) abnormal metabolism of calcium, phosphorus, parathyroid hormone (PTH) or vitamin D [1]. This evidence concerns the gene PTH and Marchiafava-Bignami disease.