Previous studies have shown that the transcription level of TLR3 was much higher (p < 0.05) in the liver of rare minnow after infection with GCRV than in the other tissues, and TLR3 regulates Mx expression and plays a crucial role in anti-GCRV immunity in the rare minnow by reducing the mortality and virus yield [44], suggesting that TLR3 may play an important role in fish defense against viral infection. The gene discussed is TLR3; the disease is viral infectious disease.