In this context, it is remarkable that Clec2d and Tnfsf10 encoding TRAIL on lrNK cells display almost the same expression time courses in response to both malaria and vaccination, in particular, a significant vaccination-accelerated decline on day 4 p.i. It is possible that TRAIL expression by lrNK cells might not only be stimulated by NCR1 [70], but might also require, directly and/or indirectly, stabilization through CLEC2D, whereas its retraction might lead to diminished expression and functioning of TRAIL on lrNK cells [80]. This evidence concerns the gene TNFSF10 and malaria.