The 5′-flanking LTR5_Hs of the tandem proviruses showed a higher H3K27Ac signal in both proliferative MITF-High and A375 cells relative to MITF-Low cells, and also significant ATAC-seq and H3K27ac signals in A375 (Figure 3A), indicating that these loci are preferentially active in the proliferative type of melanoma. The gene discussed is MITF; the disease is melanoma.