It was shown that repeated exposure of live P. gingivalis or bacteria LPS induced the release of pro-inflammatory CKs and angiotensin II in human coronary artery endothelial cells, together with P. gingivalis-associated mediators of systemic inflammation (such as CRP, IL-6, TNF-α), contributing to both endothelial dysfunction and the development of arterial hypertension [61]. This evidence concerns the gene AGT and Hypertension.