Circulating factors such as C-reactive protein (CRP) [26], soluble interleukin-6 receptor (sIL-6R) [27] and vascular endothelial growth factor (VEGF) [28] have demonstrated prognostic potential in esophageal cancer, however most studies to date have focused on squamous cell type esophageal tumors. This evidence concerns the gene CRP and esophageal cancer.