In fact, AXIN2 is not the only Wnt negative regulator known to be silenced by promoter hypermethylation in colorectal cancer: hypermethylation has been detected in negative regulators including WIF1, SFRP1/2/4, DKK1–3 and NOTUM [42,62,64]. The gene discussed is AXIN2; the disease is colorectal cancer.