In the Wisconsin Diabetes Registry Study, the following conclusions were drawn: adiponectin level decreased with age, being more stable after the age of 20 years, females had higher adiponectin levels than males, and adiponectin was strongly correlated with waist circumference, weight, BMI, HbA1C, intensive insulin management, insulin pump use, and log insulin dose [32]. The gene discussed is INS; the disease is diabetes mellitus.