In addition, although Bertrand et al. showed that TNFR1 is more critical than TNFR2 in reducing B16K1 tumor growth [15], it has also been demonstrated that TNFR2 KO mice also develop smaller tumors after implantation of Lewis Lung carcinoma and B16 cells [33]. The gene discussed is TNFRSF1B; the disease is neoplasm.