Particularly, in melanoma, tumor growth was impaired in TNF KO and TNFR1 KO but not in TNFR2 KO mice injected with B16K1 cells, a genetically-modified cell line derived from B16F10 cells, which stably express the MHC-I molecule H-2Kb [15]. The gene discussed is TNFRSF1A; the disease is neoplasm.