The etiology of bronchiectasis includes but is not restricted to, several congenital or acquired disorders including cystic fibrosis (CF), primary ciliary dyskinesia (PCD), primary immunodeficiency (PID), allergic bronchopulmonary aspergillosis, alpha-1-antitrypsin deficiency, chronic aspiration, uncontrolled asthma, chronic obstructive pulmonary disease (COPD), some rheumatologic disorders, and inflammatory bowel diseases [2]. The gene discussed is SERPINA1; the disease is cystic fibrosis.