Additionally, curcumin initiated Fas-mediated apoptotic pathway in HT-29 colon cancer via caspase 8 activation [32], and it was found to upregulate Bax expression and suppress Bcl-2 through the phosphorylation at Ser15 and activation of p53 in HT-29 colon adenocarcinoma cell [33], in HCT-116 [17] and COLO-205 cells [34]. The gene discussed is TP53; the disease is malignant colon neoplasm.