TNFRSF10B and malignant colon neoplasm: These mechanisms have been studied in vitro and in vivo in a wide variety of cancers, including colorectal and breast cancer [17,28,29,30], where curcumin was involved in several signaling pathways, including inducing tumor-necrosis-factor-related apoptosis inducing ligand (TRAIL) apoptotic pathways via upregulating death receptor 5 (DR5) in HCT-116 and HT-29 colon cancer cells [31].