The fibrin clot can also be degraded by the action of the peptidase named plasmin, which is a product of the degradation of plasminogen by the action of tissue plasminogen activator (tPA) and the urokinase-type plasminogen activator (uPA), with the latter being primarily involved in cell migration and tissue remodeling linked to the inflammation and bacterial infections. This evidence concerns the gene PLG and bacterial infectious disease.