For instance, as few as 100 CSCs (isolated and identified as CD44+ CD24-) were able to induce tumor growth in non-obese diabetic/severe combined immuno-deficient (NOD/SCID) mice [42], while in a humanized mouse model (NSGTM), injection of 1000 melanoma CD71+ cells resulted in successful tumor induction [43]. This evidence concerns the gene CD44 and neoplasm.