For example, while the proneural subtype of glioblastoma is associated with amplification in platelet-derived growth factor receptor alpha (PDGFRA), the mesenchymal subtype can be associated with alteration in neurofibromatosis type 1 (NF1), and classical subtype is associated with amplification in EGFR [76]. This evidence concerns the gene PDGFRA and glioblastoma.