The highest SIRT1 R2 value was observed for abdominal VAT (R2 = 0.61 in NW) and EFT (R2 = 0.73 in obesity), both visceral fat depots, while the lowest SIRT1 R2 value was observed for total FM % (R2 = 0.13 in AN) and trunk FM % (R2 = 0.07 in AN, R2 = 0.07 in NW, R2 = 0.12 in obesity), both mixed fat depots. The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.