AKT1 and renal cell carcinoma: Another study by Chen et al. reported the tumor suppressor role of miR-141 in renal cell carcinoma by inhibiting cell proliferation, migration, as well as invasion through targeting erythropoietin-producing hepatocellular A2 (EphA2) via modulating the EphA2/p-FAK/p-AKT/MMPs signaling cascade [45].