Gene expression profiling of whole blood collected from breast cancer survivors post-radiotherapy identified 87 differentially expressed genes, most significantly involving downregulation of TGF-β1 signaling and interleukin-2 pathways, along with upregulation of plasminogen activator inhibitor 1, a transcriptional activator inhibiting fibrinolysis [87]. The gene discussed is TGFB1; the disease is breast carcinoma.