A GWAS of 2072 North American patients identified 16 SNPs associated with PBC with the strongest association at the HLA-DQB1 locus as well as SNPs at IL12A and IL12RB2, implying a role for interleukin-12 in the development of primary biliary cirrhosis [115]. The gene discussed is IL12RB2; the disease is primary biliary cholangitis.