GWAS have identified susceptibility loci for SSc in extracellular matrix genes (COL4A3, COL4A4, COL5A2, COL22A1, COL13A1, CTGF) and autophagy (ATG5) as well as genes involved in (auto)immunity: interferon signaling (IRF4, IRF5, STAT4), interleukin signaling (IL12A, IL12RB1, IRAK1), and B-cell signaling (BANK1) (reviewed in [2,51]). The gene discussed is CCN2; the disease is systemic sclerosis.