CD80 and biliary liver cirrhosis: In Japanese cohorts, TNFSF15, POU2AF1, ARHGAP31, TMEM39A, POGLUT1, TIMMDC1, and CD80 were found to be susceptibility loci of primary biliary cholangitis [111,112], while SNP rs13720 in CTSZ was strongly associated with jaundice progression [113].