A recent in silico analysis identified further candidate modifier genes potentially involved in CFLD (i.e., Solute carrier family 33 acetyl-coenzyme A transporter member 1 (SLC33A1), glycoprotein NMB (GPNMB), neutrophil cytosolic Factor 2 (NCF2), RAS guanyl nucleotide-releasing protein 1 (RASGRP1), lectin galactosidase-binding soluble 3 (LGALS3), and protein-tyrosine phosphatase nonreceptor-type 13 (PTPN13)) [24]. The gene discussed is GPNMB; the disease is cystic fibrosis-related liver disease.