AURKB and lung carcinoma: Likewise, HOl-07 [(E)-3-((E)-4-(benzo[d][1,3]dioxol-5-yl)-2-oxobut-3-en-1-ylidene) indolin-2-one] has been found to specifically inhibit AURKB in lung cancer cells in vitro and A549 xenografts via inhibition of histone H3-Ser 10 phosphorylation in a dose- and time-dependent manner.