Conversely, Branson et al. found that obese individuals, carriers of MC4R gene mutations, met diagnostic criteria for BED, completing a validated eating disorder questionnaire [127] based on the fourth edition of Diagnostic and Statistical Manual of Mental Disorders (DMS-IV), defining BED as the major phenotype of MC4R genetic variants [15]. The gene discussed is MC4R; the disease is X-linked cone dysfunction syndrome with myopia.