MC4R and eating disorder: In contrast to the study of Hebebrand et al., in which there were no strong associations between BED and MC4R mutations, Tao et al. identified BED in obese patients with specific mutations in this receptor (T11A, F51L, T112M and M200V), without being able to explain the possible pathogenesis of the development of this eating disorder in relation to MC4R mutations [131].