Using a model of leukemic niche established by coculturing primary BM mesenchymal stromal cells (MSCs) and AML cells, we established that the BM-MSCs contact promotes in leukemic cells an overexpression of GPX3, a decrease in ROS levels, the cytoplasmic relocalization of Nrf2, and an inactivation of p38MAPK. Here, GPX3 is linked to acute myeloid leukemia.