Importantly, lncRNA-ZFAS1 exerted its function as an oncogene by direct binding DDX21 through harboring the specific motif (AAGA/CAGA) and affected its downstream target gene POLR1B stability and translation, which subsequently promoted CRC cell proliferation, migration, invasion, and suppressed cell apoptosis. The gene discussed is POLR1B; the disease is colorectal carcinoma.