Importantly, lncRNA-ZFAS1 exerted its function as an oncogene by direct binding DDX21 through harboring the specific motif (AAGA/CAGA) and affected its downstream target gene POLR1B stability and translation, which subsequently promoted CRC cell proliferation, migration, invasion, and suppressed cell apoptosis. This evidence concerns the gene ZFAS1 and colorectal carcinoma.