There was no evidence of heterogeneity in the IVW analysis for fasting glucose (Q=32.71, P=0.17), fasting insulin (Q=13.09, P=0.79), HbA1c (Q=45.20, P=0.12) and HOMA-β (Q=2.28, P=0.81), but heterogeneity was observed for type 2 diabetes (Q=67.91, P=0.007). The gene discussed is INS; the disease is type 2 diabetes mellitus.