Interestingly, IL-6 has been reported to participate with JAK2/STAT3 in a signaling pathway that promotes COAD cell proliferation [48], and the genes corresponding to the nine Hyper-DMPs and one Hypo-DMP in our COAD-specific diagnostic model were associated with the JAK/STAT pathway. The gene discussed is STAT3; the disease is colon adenocarcinoma.