By analyzing The Cancer Genome Atlas (TCGA) (Fig 1A) and the Chinese Glioma Genome Atlas (CGGA) (S1A Fig), we found that the mRNA levels of the enzymes in the de novo pyrimidine pathway, DHODH and UMPS, were elevated in high-grade glioma (IV/glioblastoma) patient samples. Here, DHODH is linked to central nervous system cancer.