Moreover, ROC curve analysis of various subgroups of ccRCC patients showed that DAPK1 expression accurately distinguished early and advanced stage patients, including (T1 + T2)/(T3 + T4) stage (Figure 3B, AUC =0.5952, P<0.001), TNM (I + II)/(III + IV) stage (Figure 3C, AUC =0.6019, P<0.0001), (G1+G2)/(G3 + G4) stage (Figure 3D, AUC =0.5666, P=0.008527), M0/M1 (Figure 3E, AUC =0.5706, P=0.04636). This evidence concerns the gene DAPK1 and nonpapillary renal cell carcinoma.