It has been proved that GM1-oligosaccharide, β-Gal-(1–3)-β-GalNAc-(1–4)-[α-Neu5Ac-(2–3)]-β-Gal-(1–4)-Glc (OligoGM1; II3Neu5Ac-Gg4), exogenously added to the culture medium of N2a neuroblastoma cells, was able alone to induce the neuritogenesis process by directly interacting with nerve growth factor (NGF)-specific receptor TrkA at the PM, reserving to the ceramide an exclusively anchor and structural role [13]. The gene discussed is NGF; the disease is neuroblastoma.