Interestingly, it has been shown that FANCD2 is particularly important for promoting MiDAS in non-cancer cells (Graber-Feesl et al., 2019). It has been shown that FANCD2 is highly expressed in mESCs, though no comparison has been made with human cancer cells, and detailed studies of FANCD2 localization in mESCs have not been conducted (Zhang et al., 2017). The gene discussed is FANCD2; the disease is cancer.