Angiotensin II infusion significantly increased the mRNA expression levels of lymphatic endothelial markers Lyve1, Pdpn, Vegfc, and Flt4 in kidney, which is consistent with previous reports (Balasubbramanian et al., 2020; Lopez Gelston et al., 2018) and represents an endogenous expansion in response to systemic hypertension. This evidence concerns the gene FLT4 and Hypertension.