Of the other three studies, depending on transgenic mice with tyrosinase‐specific T cell clone,167 transgenic mice carrying T cells with an HLA‐A2 restricted human tyrosinase reactive T cell receptor (TCR)168 and mice manifesting melanoma‐induced autoimmune symptoms (vitiligo‐like white coat),143 respectively, the former two regard perforin as an unnecessary mechanism in melanocyte destruction. This evidence concerns the gene TYR and melanoma.