For example, Andersen-Tawil syndrome, a rare human disorder that arises due to mutations in Kir2.1 channels, causes morphological defects including craniofacial dysmorphologies as well as clinodactyly (permanent curvature of a finger or toe) or syndactyly (webbing between finger) (Plaster et al., 2001). The gene discussed is KCNJ2; the disease is Cardiodysrhythmic potassium-sensitive periodic paralysis.