And most of the 24 DEPs (CDK1, SFN, PRKAR2B, MKI67 and MDK involved in the cell cycle; LOXL2, P4HA1, P4HA2, SPRX, DES, PRPH and CALML3 involved in construction and regulation of extracellular matrix; IL33 and EHD3 may involve in immune) were linked to cancer hallmarks. This evidence concerns the gene DES and cancer.