Further future studies are needed to fully elucidate the relationship between rno-miR-146b-5p and Klf4, determine the functions of Klf4 and rno-miR-146b-5p in vivo through overexpression or interference techniques, identify the relationship between Klf4 and Ccnd2, and identify the miR-146b-5p/Klf4/Ccnd2 cascade in the development of sepsis in vivo. Here, KLF4 is linked to Sepsis.