Moreover, corroborating improvement in Stat3 phosphorylation, we also demonstrated ameliorated markers of protein catabolism, such as protein ubiquitination and the E3 ubiquitin ligases Atrogin‐1 and Murf‐1, which we and others have previously demonstrated in association with cachexia, including HCT116 LM (Figure4).12, 51, 57, 58. The gene discussed is STAT3; the disease is Cachexia.