In contrast with data previously reported in APCmin/ + mice, another model for the study of CRC cachexia,40 the mHCT116 hosts presented reduced phosphorylation of AKT (−43%, P < 0.05 vs. S), which was not statistically different from S in the mice receiving the treatment (FigureS9B). The gene discussed is AKT1; the disease is colorectal carcinoma.