Our findings also provide evidence of a Stat3–ACVR2B link in CRC‐induced cachexia (Figure4), in line with results by Zhang et al. showing that Stat3 mediates downstream signalling of ACVR2B/activin receptor‐like kinase (ALK4) in promoting myofibroblast differentiation.56 Here, STAT3 is linked to colorectal carcinoma.