EIF4EBP1 and Cachexia: Similarly, in line with the idea that unbalanced protein homeostasis (i.e. proteostasis) represents one of the hallmarks of cachexia,3 we and others have also shown that markers of anabolism are suppressed in mouse models for the study of CRC cachexia, as suggested by reductions of phosphorylated mTOR, 4EBP1, and p70S6K within skeletal muscle.10, 59