We and others have implicated the transcription factor Stat3 in the progression of cachexia in several experimental models, including the C26 allograft, C26 LM and Apcmin/ + CRC models, as well as the Lewis Lung Carcinoma, B16 melanoma, and ES‐2 ovarian cancer models.46, 47, 48, 49, 50, 51, 52, 53, 54, 55. Here, STAT3 is linked to melanoma.