In rat chondrosarcoma (RCS) chondrocytes and control human R00‐082 chondrocytes, treatment with GRK2 inhibitor CPMD101 produced no effect on LRP6 protein expression, but inhibited the Wnt3A‐mediated phosphorylation of LRP6 on T1572 and S1490 (Fig 7C and D). The gene discussed is WNT3A; the disease is chondrosarcoma.