The series included 6 cases: 3 meningiomas, 1 craniopharyngioma, 1 ACTH-secreting adenoma and 1 pituicytoma, managed at the Pituitary Unit of the IRCCS Istituto delle Scienze Neurologiche di Bologna, and at the Neurosurgical Department of the Fondazione IRCCS Policlinico San Matteo, Pavia (Italy), since 2000 to 2019. This evidence concerns the gene POMC and adenoma.