Second, ACTH-secreting tumors are quite rare but associated with high rate of complications for the mother (i.e. hypertension or preeclampsia, diabetes, fractures; more rarely, cardiac failure, psychiatric disorders, infection and maternal death) and the fetus (i.e. prematurity, intrauterine growth retardation, and less prevalently stillbirth, spontaneous abortion, intrauterine death, and hypoadrenalism) [34, 36, 37]. Here, POMC is linked to psychiatric disorder.