The plasma concentration of inflammatory cytokines tended to be lower for VPS than for APS, with significant differences for some (TNF-α: p = 0.005; IL-6: p = 0.065; IL-1β: p = 0.029; IL-8: p = 0.002; IFN-γ: p = 0.200). The gene discussed is IL1B; the disease is autoimmune polyendocrinopathy.