ADA and B-cell chronic lymphocytic leukemia: Also consistent with previous results obtained with ELISA showing an increase in CLL of 1.12 (95% credible interval (CDI), 1.05–1.20), the presence of ADA detected by the ECL assay was estimated to increase vedolizumab CLL by a factor of 1.10 (95% CDI, 1.03–1.17) (Table VII).