Conversely, an inappropriate increase in NCC activity due to mutations in NCC-regulating with no lysine (K) kinases (WNK1 and 4) or ubiquitin ligase complexes (KLHL3, CUL3) causes salt-sensitive familial hyperkalemic hypertension (FHHt) with metabolic acidosis and hypercalciuria, also known as Gordon syndrome or pseudohypoaldosteronism type II (PHA II) [12, 28, 41]. The gene discussed is SLC12A3; the disease is metabolic acidosis.