In the context of haematologic malignancies, these new approaches include CAR-T cells targeted against B cell maturation antigen in relapsed or refractory multiple myeloma [80, 81] and CAR-T cells targeted against CD22 in acute lymphoblastic leukaemia, last of which managed to achieve stunning CR rates of over 80% in patients treated at the highest-dose level in a phase I trial [3, 82]. This evidence concerns the gene CD22 and acute lymphoblastic leukemia.