Moreover, in AML cell lines Ven-PegC significantly decreased protein levels of MCL-1 (but not BCL-2 or BCL-XL), whose translation is highly dependent on 4EBP1/eIF4E activity on mRNA-capping (Fig. 6b and Supplementary Fig. S10D) [37, 38]. This evidence concerns the gene BCL2 and acute myeloid leukemia.