Glutamine depletion induced by L-asparaginases was reported to inhibit 4EBP1 (a tumor suppressor regulated by oncogenic mTOR pathway) phosphorylation at residue S65 and decrease protein synthesis in AML cell lines, with a fourfold greater effect with Erwinia asparaginase than with E coli asparaginase [13]. Here, ASPG is linked to acute myeloid leukemia.